Human blood plasma-based electronic integrated circuit amplifier configuration

Corresponding author: Dr. S.P Kosta, Director General, Shri Ram Group of Institutions, Jabalpur, MP, India. Advisor, Charotar University of Science and Technology, At&Po: Changa Ta: Petlad Dist: Dear Editor: There is accumulating evidence that human blood electronic circuit components and their application circuits become more and more important to cyborg implant/engineering, man-machine interface, human disease detection and healing, and artificial brain evolution. Here, we report the first development of human plasma-based amplifier circuit in the discrete as well as integrated circuit (IC) configuration mode. Electrolytes in the human blood contain an enormous number of charge carriers such as positive and negative molecule/atom ions, which are electrically conducting media and therefore can be utilized for developing electronic circuit components and their application circuits. These electronic circuits obviously have very high application impact potential towards bio-medical engineering and medical science and technology. The experimental human blood plasma serum sample amplifier circuit layout with theoretical amplifier circuit is shown in Fig. 1 and 2. Theoretically, a transistor has two diodes in the back to back configuration with three probes made of rectangular cooper strips (1-8 mm), probe B (the base terminal), C (the collector terminal) and E (the emitter terminal) placed in human plasma serum electrolytes (Fig. 1). Under direct current (DC) voltage bias conditions, electrical field coupling between the base and the emitter probes and the collector-emitter probes occurred due to inherent capacitance/inductance coupling. The geometry and distance between the forming diode (set of 3 probes B, E, C) play vital roles in the practical realization of the transistor. The input circuit (base-emitter) contained variable voltage power supply with current measuring multi-meter to measure voltage/current input characteristics (VBE v/s IBE by keeping VCE constant) between the base and the emitter. Similar output circuit was realized by another variable voltage supply with multimeter (VCE v/s ICE by keeping VBE constant) between the collector and the emitter. The developed bio-logical transistor showed technically acceptable (compared with conventional semi-conductor device) input and output characteristics of the device (Fig. 3A, 3B). The β was found to vary from 5 to 15. For the realization of resistance R and capacitance C, two rectangular (1 mm×2 mm) shaped cooper wire probes were inserted in the human blood plasma serum sample and the distance between the two probes was varied to realize appropriate resistance and capacitance values. The charged particles under the influence of EMF acquire dynamism and face collisions and thus they manifest resistance R. Similarly, charged molecules and atoms in human blood plasma serum dynamically manifest capacitance C.